Curcumol is a sesquiterpene alcohol that has been found in Curcumae oil and has diverse biological activities.It is a positive allosteric modulator (PAM) of GABAA receptors that potentiates GABA-induced currents in the presence of the benzodiazepine GABA agonist diazepam, but not the GABAA PAM (–)-menthol, in mouse hippocampal neurons.Curcumol (1-200 μg/ml) reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract.It inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells in a concentration-dependent manner. In vivo, curcumol (20-80 mg/kg) reduces tumor volume in a LoVo mouse xenograft model. Curcumol also increases the rate of wound closure in rats with diabetes induced by streptozotocin (Cat No. PC-59260).

C₁₅H₂₄O₂

DMSO