APR-246
(PRIMA-1Met)APR-246是一种突变型 p53 复活剂，可恢复突变型 p53 的野生型构象和功能，并引发肿瘤细胞凋亡
CAS NO.：5291-32-7
| 规格 | 价格 | 库存 |
|---|---|---|
| 5mg | 650.00 | 现货 |
| 10mg | 1050.00 | 现货 |
| 25mg | 2100.00 | 现货 |
| 50mg | 3600.00 | 现货 |
基本信息
|
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Cat No. PC-39960) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.PRIMA-1MET（APR-246） is a methylated derivative of PRIMA-1 that restores tumor-suppressor function to mutant p53 and induces cell death in various cancer cell lines.3 PRIMA-1MET can synergize with chemotherapeutic drugs to induce tumor cell apoptosis.At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance. |
|
| CAS | 5291-32-7 |
| 分子量 | 199.25 |
| 分子式 |
C10H17NO3 |
| 溶剂 |
H2O |
| 纯度 | 98% |
| 存储温度 | -20℃ |
相关说明文档
储备液配置
|
浓度
体积
质量
|
1mg | 5mg | 10mg |
| 1 mM | 5.0188 mL | 25.0941 mL | 50.1882 mL |
| 5 mM | 1.0038 mL | 5.0188 mL | 10.0376 mL |
| 10 mM | 0.5019 mL | 2.5094 mL | 5.0188 mL |
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