Nonivamide
(NSC 172795;Pseudocapsaicin)合成类的辣椒素
CAS NO.:2444-46-4
规格 | 价格 | 库存 |
---|---|---|
500mg | 600.00 | 现货 |
1g | 1000.00 | 现货 |
5g | 3800.00 | 现货 |
10g | 6000.00 | 现货 |
基本信息
Nonivamide is a transient receptor potential vanilloid type 1 (TRPV1) agonist and an analog of capsaicin (Cat No. PC-27651) that has been isolated from Capsicum species.It is toxic to NHBE, BEAS-2B, and BEAS-2B cells overexpressing TRPV1 (TRPV1-OE; LC50s = 160, 115, and 1 µM, respectively), increases calcium flux in TRPV1-OE cells (EC50 = 1.4 µM), and increases GADD153 mRNA expression by 7- and 6-fold when used at concentrations of 2 and 20 µM, respectively.Nonivamide (1 µM) also increases the release of dopamine and serotonin from SH-SY5Y cells in a calcium-dependent and TRPV1-independent manner.In mice, it reduces respiration when inhaled and is toxic with LD50 values of 200 and 413 mg/kg for oral and inhaled administration, respectively.Formulations containing nonivamide have been used in pepper spray weaponry for riot control. |
|
CAS | 2444-46-4 |
分子量 | 293.4 |
分子式 |
C17H27NO3 |
溶剂 |
DMSO |
纯度 | 98% |
存储温度 | -20℃ |
相关说明文档
储备液配置
浓度
体积
质量
|
1mg | 5mg | 10mg |
1 mM | 3.4083 mL | 17.0416 mL | 34.0832 mL |
5 mM | 0.6817 mL | 3.4083 mL | 6.8166 mL |
10 mM | 0.3408 mL | 1.7042 mL | 3.4083 mL |
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