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Atractylenolide III

  (ICodonolactone ; 8β-Hydroxyasterolide)
目录号: PC-20237

有诱导肺癌细胞凋亡活性。

CAS NO.:73030-71-4

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规格 价格 库存
10mg 1810.00 现货
20mg 2900.00 现货
50mg 4700.00 现货

基本信息

Atractylenolide III is a sesquiterpene that has been isolated from Atractylodes and has diverse biological activities, including anti-inflammatory, anti-angiogenic, pro- and anti-apoptotic, and neuroprotective properties.It inhibits the release of nitric oxide (NO), prostaglandin E2 , TNF-α, and IL-6 induced by LPS from RAW264.7 macrophages when used at a concentration of 50 µM.Atractylenolide III (100 µM) induces apoptosis and cell cycle arrest, as well as increases caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP) cleavage in A549 human lung carcinoma cells.However, in primary embryonic mouse cerebral cortical neurons, it inhibits glutamate-induced apoptosis and DNA fragmentation when used at a concentration of 40 µM. It inhibits angiogenesis in an MDA-MB-231 human breast cancer mouse xenograft model when administered at a dose of 25 mg/kg per day.Atractylenolide III (0.6 mg/kg per day) also decreases the latency to find the platform in the Morris water maze in a rat model of learning deficits induced by high-dose homocysteine.

CAS 73030-71-4
分子量 248.32
分子式

C₁₅H₂₀O₃

溶剂

DMSO

纯度 98%
存储温度 -20℃

相关说明文档

储备液配置

浓度 体积 质量
1mg 5mg 10mg
1 mM 4.0271 mL 20.1353 mL 40.2706 mL
5 mM 0.8054 mL 4.0271 mL 8.0541 mL
10 mM 0.4027 mL 2.0135 mL 4.0271 mL
注:请根据所选浓度进行配置储备液,配置好储备液后进行分装低温保存,避免反复冻融!PCM提供多种溶剂,如:DMSO(PC-57930);玉米油(PC-86094);棉籽油(PC-30875)等

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