Atractylenolide III
(ICodonolactone ; 8β-Hydroxyasterolide)有诱导肺癌细胞凋亡活性。
CAS NO.:73030-71-4
规格 | 价格 | 库存 |
---|---|---|
10mg | 1810.00 | 现货 |
20mg | 2900.00 | 现货 |
50mg | 4700.00 | 现货 |
基本信息
Atractylenolide III is a sesquiterpene that has been isolated from Atractylodes and has diverse biological activities, including anti-inflammatory, anti-angiogenic, pro- and anti-apoptotic, and neuroprotective properties.It inhibits the release of nitric oxide (NO), prostaglandin E2 , TNF-α, and IL-6 induced by LPS from RAW264.7 macrophages when used at a concentration of 50 µM.Atractylenolide III (100 µM) induces apoptosis and cell cycle arrest, as well as increases caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP) cleavage in A549 human lung carcinoma cells.However, in primary embryonic mouse cerebral cortical neurons, it inhibits glutamate-induced apoptosis and DNA fragmentation when used at a concentration of 40 µM. It inhibits angiogenesis in an MDA-MB-231 human breast cancer mouse xenograft model when administered at a dose of 25 mg/kg per day.Atractylenolide III (0.6 mg/kg per day) also decreases the latency to find the platform in the Morris water maze in a rat model of learning deficits induced by high-dose homocysteine. |
|
CAS | 73030-71-4 |
分子量 | 248.32 |
分子式 |
C₁₅H₂₀O₃ |
溶剂 |
DMSO |
纯度 | 98% |
存储温度 | -20℃ |
相关说明文档
储备液配置
浓度
体积
质量
|
1mg | 5mg | 10mg |
1 mM | 4.0271 mL | 20.1353 mL | 40.2706 mL |
5 mM | 0.8054 mL | 4.0271 mL | 8.0541 mL |
10 mM | 0.4027 mL | 2.0135 mL | 4.0271 mL |
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