Febuxostat
(TEI 6720; TMX 67；FBX)Febuxostat (TEI 6720) 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
CAS NO.：144060-53-7
| 规格 | 价格 | 库存 |
|---|---|---|
| 10mg | 500.00 | |
| 50mg | 1200.00 | 现货 |
| 100mg | 1950.00 | 现货 |
基本信息
|
Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase.It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively).Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg).It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day.Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE).Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout. |
|
| CAS | 144060-53-7 |
| 分子量 | 316.37 |
| 分子式 |
C16H16N2O3S |
| 溶剂 |
DMSO |
| 纯度 | 98% |
| 存储温度 | -20℃ |
相关说明文档
储备液配置
|
浓度
体积
质量
|
1mg | 5mg | 10mg |
| 1 mM | 3.1609 mL | 15.8043 mL | 31.6086 mL |
| 5 mM | 0.6322 mL | 3.1609 mL | 6.3217 mL |
| 10 mM | 0.3161 mL | 1.5804 mL | 3.1609 mL |
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