产品描述：Interleukin-1 beta (IL-1β) is a major cytokine expressed in macrophage, NK cells, monocytes, and neutrophils. It also plays                    fundamental role in inflammatory response, including monocyte activation, which is essential for the host defense and pathogen                  and pathogen resistance. Pro-IL-1β is cleaved by cytosolic caspase 1 to form mature IL-1β.

别名：interleukin 1 beta,

          Catabolin, Lymphocyte-Activating Factor (LAF),

          Endogenous Pyrogen (EP),

          Leukocyte Endogenous Mediator (LEM),

          Mononuclear Cell Factor (MCF),

          IL1,

          IL1B

蛋白编号：P01584

表达系统：Escherichia coli

纯度：>98% as determined by SDS-PAGE.

生物活性：Measure by its ability to induce IL-8 secretion in HT29 cells. The ED₅₀ for this effect is <2.0 ng/mL. The specific activity of                     recombinant human IL-1 beta is approximately >5 x 10⁷ IU/mg.

分子量：The protein has a calculated MW of 18.5 kDa. The protein migrates as 17 kDa under reducing condition (SDS-PAGE analysis).

内毒素：<0.1 EU per 1 μg of the protein by the LAL method..

蛋白序列：ASAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYP

       KKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS with polyhistidine tag at the C-terminus.

标签：His Tag (C-term)

产品形式：The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0. If you have any concerns or special                     requirements, please confirm with us.

保存条件：Lyophilized Protein: Store at -20°C for 1 year.

                 Initial Reconstitution: Store at 2°C to 8°C for up to 1 week.

                 Extended Storage: Store at -20°C or -80°C for 3 to 6 months with a carrier protein or stabilizer.

SDS-PAGE analysis of recombinant human IL-1 beta