3-Methyladenine
(3-MA)3-Methyladenine (3-MA) 是 PI3K 的抑制剂。它通过抑制class III PI3K广泛作为自噬 (autophagy) 的抑制剂使用。
CAS NO.:5142-23-4
规格 | 价格 | 库存 |
---|---|---|
50mg | 550.00 | 现货 |
100mg | 780.00 | 现货 |
200mg | 1350.00 | 现货 |
500mg | 2600.00 | 现货 |
基本信息
Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-kinase (PI3K), is a key regulator of autophagy.3-Methyladenine (3-MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome.At 5 mM, 3-MA inhibits protein degradation in rat hepatocytes by 65%.3-MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM. |
|
CAS | 5142-23-4 |
分子量 | 149.15 |
分子式 |
C6H7N5 |
溶剂 |
DMSO/H2O |
纯度 | 98% |
存储温度 | -20℃ |
相关说明文档
储备液配置
浓度
体积
质量
|
1mg | 5mg | 10mg |
1 mM | 6.7047 mL | 33.5233 mL | 67.0466 mL |
5 mM | 1.3409 mL | 6.7047 mL | 13.4093 mL |
10 mM | 0.6705 mL | 3.3523 mL | 6.7047 mL |
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