Rapamycin
(Sirolimus; AY-22989)雷帕霉素是mTOR的特异性抑制剂。雷帕霉素可在无血清培养基中抑制Rh1和Rh30横纹肌肉瘤细胞的生长。
CAS NO.：53123-88-9
| 规格 | 价格 | 库存 |
|---|---|---|
| 10mg | 500.00 | 现货 |
| 25mg | 750.00 | 现货 |
| 50mg | 1000.00 | 现货 |
| 100mg | 1400.00 | 现货 |
| 500mg | 4800.00 | 现货 |
基本信息
|
Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1).It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml.It also induces autophagy in a variety of cell types. Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM.Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection. |
|
| CAS | 53123-88-9 |
| 分子量 | 914.17 |
| 分子式 |
C51H79NO13 |
| 溶剂 |
DMSO |
| 纯度 | 98% |
| 存储温度 | -20℃ |
相关说明文档
储备液配置
|
浓度
体积
质量
|
1mg | 5mg | 10mg |
| 1 mM | 1.0939 mL | 5.4694 mL | 10.9389 mL |
| 5 mM | 0.2188 mL | 1.0939 mL | 2.1878 mL |
| 10 mM | 0.1094 mL | 0.5469 mL | 1.0939 mL |
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