Rabbit Polyclonal Osteocalcin Antibody
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein in chick bone. Because osteocalcin has gla domains, its synthesis is vitamin K dependent. In humans, osteocalcin is encoded by the BGLAP gene. Its receptors include GPRC6A, GPR158, and possibly a third, yet-to-be-identified receptor. Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body's metabolic regulation. In its carboxylated form it binds calcium directly and thus concentrates in bone, but genetic evidence has revealed that it does not play an important role in bone mineralization. In its uncarboxylated form, osteocalcin acts as a hormone in the body, signalling in the pancreas, fat, muscle, testes, and brain. An Acute Stress Response (ASR) (colloquially known as the fight or flight response) stimulates osteocalcin release from bone within minutes in mice, rats, and humans. Injections of high levels of osteocalcin alone can trigger an ASR in the presence of adrenal insufficiency.
| 规格 | 价格 | 库存 |
|---|---|---|
| 50ul | 1800.00 | 现货 |
| 100ul | 3200.00 | 现货 |
基本信息
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名称：兔多克隆Osteocalcin抗体 描述：Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein in chick bone. Because osteocalcin has gla domains, its synthesis is vitamin K dependent. In humans, osteocalcin is encoded by the BGLAP gene. Its receptors include GPRC6A, GPR158, and possibly a third, yet-to-be-identified receptor. Osteocalcin is secreted solely by osteoblasts and thought to play a role in the body's metabolic regulation. In its carboxylated form it binds calcium directly and thus concentrates in bone, but genetic evidence has revealed that it does not play an important role in bone mineralization. In its uncarboxylated form, osteocalcin acts as a hormone in the body, signalling in the pancreas, fat, muscle, testes, and brain. An Acute Stress Response (ASR) (colloquially known as the fight or flight response) stimulates osteocalcin release from bone within minutes in mice, rats, and humans. Injections of high levels of osteocalcin alone can trigger an ASR in the presence of adrenal insufficiency. 克隆：多克隆 别称：BGLAP antibody BGP antibody Bone gamma carboxyglutamate (gla) protein antibody Bone gamma carboxyglutamate gla protein osteocalcin antibody Bone gamma carboxyglutamate protein antibody Bone Gla protein antibody Gamma carboxyglutamic acid containing protein antibody Gamma-carboxyglutamic acid-containing protein antibody OC antibody OCN antibody OSTCN_HUMAN antibody Osteocalcin antibody OTTHUMP00000016586 antibody PMF1 antibody 纯化方式：Protein A affinity purified. 宿主：Rabbit/IgG 种属反应性：Human，Mouse，Rat，Dog，Pig 经测试应用：WB，IHC-P，IF/ICC 预测分子量：11kDa 抗原：KLH conjugated synthetic peptide derived from human Osteocalcin:21-100/100 应用： WB：1:500-1000 IHC-P：1:50-200 IF/ICC: 1:50-200 存储形式：Liquid 存储液：PBS with 0.09% Sodium azide,50% glycerol,pH7.3. 储存温度：-20℃
Sample:
Paraformaldehyde-fixed, paraffin embedded (human skeletal muscle); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37℃ for 30min; Incubation with Rabbit Polyclonal Osteocalcin Antibody , Rabbit Polyclonal Osteocalcin Antibody at 1:100 overnight at 4℃, followed by operating according to SP Kit(Rabbit) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Blocking buffer (normal goat serum) at 37℃ for 30min; Incubation with (Osteocalcin) Polyclonal Antibody, Rabbit Polyclonal Osteocalcin Antibody at 1:100 overnight at 4℃, followed by a conjugated Goat Anti-Rabbit IgG antibody for 90 minutes, and DAPI for nuclei staining
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| 存储温度 | -20℃ |
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