名称：Guinea pig Recombinant Homer1 antibody

描述：Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity).

抗体类型：Recombinant Chimeric Antibody

宿主：豚鼠 IgG2

种属反应性：Mouse，Rat

经测试应用：WB，IHC-Fr

预测分子量：40kDa

纯化方式：Protein A affinity purified.

阳性对照：Mouse brain tissue lysate, Rat brain tissue lysate.

抗原：Recombinant protein within human Homer1 aa 101-250/354.

浓度：WB：1:1000-2000        IHC-Fr：1:50-200

存储液：PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

储存温度：-20℃,避免污染

Western blot analysis of Homer1 on different lysates with Guinea pig anti-Homer1 antibody at 1/10,000 dilution.

Lysates/proteins at 20 µg/Lane.

Exposure time: 4 seconds; ECL: PC-30002;
4-20% SDS-PAGE gel.

Application: IHC-Fr

Species: Mouse

Site: hippocampus

Sample: Frozen section

Antibody concentration: 1/200

Antigen retrieval: Not required