GKT137831
(GKT831；Setanaxib)GKT137831是选择性的NADPH氧化酶 (NOX1/4) 抑制剂
CAS NO.：1218942-37-0
| 规格 | 价格 | 库存 |
|---|---|---|
| 5mg | 1050.00 | 现货 |
| 10mg | 1900.00 | 现货 |
| 50mg | 5800.00 | 现货 |
| 100mg | 7800.00 | 现货 |
基本信息
|
NADPH oxidase 1 (NOX1) and NOX4 generate reactive oxygen species (ROS) that are critical in regulating a variety of cellular functions but also contribute to many diseases.GKT137831 is a dual inhibitor of both NOX1 and NOX4 with Ki values in the range of 100 to 150 nM in cell-free assays of ROS production.It shows only weak inhibitory activity against NOX2 or xanthine oxidase and does not block neutrophil oxidative burst, scavenge ROS, or have antioxidant activity.GKT137831 displays good oral bioavailability with high plasma concentrations in vivo and attenuates liver fibrosis in mice.It reduces hypoxia-induced pulmonary vascular cell proliferation, ameliorates dopaminergic neuronal death, and provides renoprotection in long-term diabetic nephropathy. |
|
| CAS | 1218942-37-0 |
| 分子量 | 394.85 |
| 分子式 |
C21H19ClN4O2 |
| 溶剂 | DMSO |
| 纯度 | 98% |
| 存储温度 | -20℃ |
相关说明文档
储备液配置
|
浓度
体积
质量
|
1mg | 5mg | 10mg |
| 1 mM | 2.5326 mL | 12.6630 mL | 25.3261 mL |
| 5 mM | 0.5065 mL | 2.5326 mL | 5.0652 mL |
| 10 mM | 0.2533 mL | 1.2663 mL | 2.5326 mL |
相关产品推荐
Peoniflorin（芍药苷）是来自于芍药的根部，在中医理论上是有止痛属性，抗心肌缺血，镇痛，抗炎，耐缺氧等作用。
Luteolin is a non-selective phisphodiesterase PDE inhibitor
Propranolol hydrochloride 是一种非选择性的肾上腺素受体拮抗剂，Propranolol hydr
α-solanine 是马铃薯中的一种生物活性成分，Alpha-Solanine可改变脂肪和肠中的抗氧化酶活性，MDA和
浏览历史产品
Heparan sulfate 是一种复杂的线性多糖。Heparan sulfate 作为硫酸乙酰肝素蛋白聚糖的一部分出
曲美替尼Trametinib DMSO solvate 是有效的 MEK 抑制剂，抑制MEK1 和 MEK2的IC50
Tectoridin 是一种从 Maackia amurensis 分离的异黄酮。Tectoridin 是一种植物雌激素
(R)-(+)-Corypalmine shows strong papaverine-like activity。