Rabbit Polyclonal IL-12RB2 antibody
Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified in all mammals for which complete genome data are available. The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation.
| 规格 | 价格 | 库存 |
|---|---|---|
| 50ul | 1800.00 | 现货 |
| 100ul | 3200.00 | 现货 |
基本信息
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名称：兔多克隆 IL-12RB2 抗体 描述：Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified in all mammals for which complete genome data are available. The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. 宿主：Rabbit / IgG 纯化方式：Immunogen affinity purified. 别名：Interleukin 12 receptor beta 2; IL-12R-beta-2 ; IL12RB2; RP11 102M16.1 种属反应性：Human 经测试应用：WB，IHC-P，IF/ICC 浓度：1mg/ml 抗原：Synthetic peptide within human IL-12RB2 aa 751-800. 分子量：~97 kDa 亚细胞定位：Membrane. 稀释比： WB：1:100-500 IHC-P：1:50-500 ICC/IF：1:50-200 存储液： PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. 储存温度：-20℃
Western blot analysis of IL-12RB2 on different lysates with Rabbit anti-IL-12RB2 antibody at 1/2,000 dilution.
Immunocytochemistry analysis of Hela cells labeling IL-12RB2 with Rabbit anti-IL-12RB2 antibody at 1/200 dilution.
Immunohistochemical analysis of paraffin-embedded human placenta tissue with Rabbit anti-IL-12RB2 antibody at 1/600 dilution. |
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| 存储温度 | -20℃ |
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