Cytarabine
(Cytosine β-D-arabinofuranoside)阿糖胞苷是DNA聚合酶抑制剂的和苷类类似物。
CAS NO.:147-94-4
规格 | 价格 | 库存 |
---|---|---|
100mg | 450.00 | 现货 |
500mg | 880.00 | 现货 |
1g | 1500.00 | 现货 |
基本信息
Cytarabine (ara-C) is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase.Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines with IC50 values of 37, 17, 16, and 72 nM, respectively.It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 2.5 and 15 µM.ara-C (75 mg/kg per day, i.p.) reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model.It also increases survival and reduces brain herpesvirus titers in infected rats when administered subcutaneously at doses of 80 and 320 mg/kg.Formulations containing ara-C have been used in the treatment of acute myeloid leukemia. |
|
CAS | 147-94-4 |
分子量 | 243.22 |
分子式 |
C₉H₁₃N₃O₅ |
溶剂 |
H2O/DMSO |
纯度 | 98% |
存储温度 | -20℃ |
相关说明文档
储备液配置
浓度
体积
质量
|
1mg | 5mg | 10mg |
1 mM | 4.1115 mL | 20.5575 mL | 41.1150 mL |
5 mM | 0.8223 mL | 4.1115 mL | 8.2230 mL |
10 mM | 0.4112 mL | 2.0558 mL | 4.1115 mL |
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