NAPQI
(N-Acetyl-p-benzoquinonimine；N-(4-oxo-2,5-cyclohexadien-1-ylidene)-acetamide)N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses.
CAS NO.：50700-49-7
| 规格 | 价格 | 库存 |
|---|---|---|
| 500ug | 1300.00 | 现货 |
| 1mg | 2500.00 | 现货 |
| 5mg | 9950.00 | 现货 |
基本信息
|
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses.At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis. |
|
| CAS | 50700-49-7 |
| 分子量 | 149.15 |
| 分子式 |
C8H7NO2 |
| 溶剂 |
DMSO |
| 纯度 | 98% |
| 存储温度 | -20℃ |
相关说明文档
参考文献
|
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses.At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis. |
储备液配置
|
浓度
体积
质量
|
1mg | 5mg | 10mg |
| 1 mM | 6.7047 mL | 33.5233 mL | 67.0466 mL |
| 5 mM | 1.3409 mL | 6.7047 mL | 13.4093 mL |
| 10 mM | 0.6705 mL | 3.3523 mL | 6.7047 mL |
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