Atractylenolide I
TLR4 的拮抗剂,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。
CAS NO.:73069-13-3
规格 | 价格 | 库存 |
---|---|---|
5mg | 880.00 | 现货 |
10mg | 1420.00 | 现货 |
50mg | 4700.00 | 现货 |
基本信息
Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties.It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively).Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund's complete adjuvant (FCA).It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity. |
|
CAS | 73069-13-3 |
分子量 | 230.3 |
分子式 |
C₁₅H₁₈O₂ |
溶剂 |
DMSO |
纯度 | 98% |
存储温度 | -20℃ |
相关说明文档
储备液配置
浓度
体积
质量
|
1mg | 5mg | 10mg |
1 mM | 4.3422 mL | 21.7108 mL | 43.4216 mL |
5 mM | 0.8684 mL | 4.3422 mL | 8.6843 mL |
10 mM | 0.4342 mL | 2.1711 mL | 4.3422 mL |
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