Tubeimoside I is a natural triterpenoid saponin isolated from the medicinal herb B. paniculatum which possesses broad anticancer activity.Tubeimoside I exhibits antiproliferative activity against hepatoma HepG2 cells (IC50 = 15.5 μM) and induces nuclear condensation and fragmentation, cell cycle arrest, mitochondrial membrane disruption, and activation of caspase-3 and caspase-9.Treatment of HeLa cells with tubeimoside I (IC50 = 25 μM) similarly initiates mitochondrial dysfunction, endoplasmic reticulum stress, and cytoskeletal rearrangement.In vivo, tubeimoside I (5 mg/kg) administration to nude mice with flank xenografts of human large-cell lung carcinoma cells decreases tumor volume and microvessel density.It also decreases metastasis of breast cancer cell line MDA-MB-231 in vivo by decreasing expression of C-X-C chemokine receptor type 4 (CXCR4).

C₆₃H₉₈O₂₉

DMSO