Pulchinenoside A3
(Anemoside A3)Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death when used at a concentration of 30 μM.Pulchinenoside A (30 and 100 mg/kg) increases the levels of serotonin, 5-hydroxyindolacetic acid , and norepinephrine in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice. It reduces the time spent immobile in the forced swim test in mice when administered at doses of 30 and 100 mg/kg and increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg. Pulchinenoside A (12.6 and 25.2 mg/kg) reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner.
CAS NO.:129724-84-1
规格 | 价格 | 库存 |
---|---|---|
5mg | 680.00 | 现货 |
10mg | 1150.00 | 现货 |
20mg | 2070.00 | 现货 |
基本信息
Pulchinenoside A is a triterpenoid saponin that has been found in Pulsatilla chinensis and has diverse biological activities.It inhibits NMDA-evoked currents in hippocampal neurons (IC50s = 18.48 and 20.19 μM at -50 and +50 mV, respectively) and inhibits NMDA-induced neuronal cell death when used at a concentration of 30 μM.Pulchinenoside A (30 and 100 mg/kg) increases the levels of serotonin, 5-hydroxyindolacetic acid , and norepinephrine in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice. It reduces the time spent immobile in the forced swim test in mice when administered at doses of 30 and 100 mg/kg and increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg. Pulchinenoside A (12.6 and 25.2 mg/kg) reduces infarct volume in a middle cerebral artery occlusion (MCAO) rat model of ischemia. It also induces relaxation of precontracted isolated rat thoracic aorta and renal, mesenteric, and left coronary arteries in a concentration-dependent manner. |
|
CAS | 129724-84-1 |
分子量 | 750.96 |
分子式 |
C₄₁H₆₆O₁₂ |
溶剂 |
DMSO |
纯度 | 98% |
存储温度 | -20℃ |
相关说明文档
储备液配置
浓度
体积
质量
|
1mg | 5mg | 10mg |
1 mM | 1.3316 mL | 6.6581 mL | 13.3163 mL |
5 mM | 0.2663 mL | 1.3316 mL | 2.6633 mL |
10 mM | 0.1332 mL | 0.6658 mL | 1.3316 mL |
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