Erastin
Erastin 是铁诱导的细胞死亡 (ferroptosis) 诱导剂。Erastin 结合且抑制电压依赖性阴离子通道 (VDAC2/VDAC3)。
CAS NO.：571203-78-6
| 规格 | 价格 | 库存 |
|---|---|---|
| 5mg | 725.00 | 现货 |
| 10mg | 1350.00 | 现货 |
| 50mg | 4500.00 | 现货 |
基本信息
|
Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer.It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Cat No. PC-100652), ferrostatin-1 (Cat No. PC-53956), U-0126 (Cat No. PC-56408), cycloheximide (Cat No. PC-57630), and β-mercaptoethanol. Erastin (5 µM) inhibits cystine uptake by the system xc- cystine-glutamate transporter in HT-1080 fibrosarcoma and Calu-1 lung carcinoma cells and inhibits glutamate release in an enzyme-coupled fluorescence assay (EC50 = 1.2 µM). It also selectively induces cell death in cells expressing the SV40 small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 µg/ml). |
|
| CAS | 571203-78-6 |
| 分子量 | 547.04 |
| 分子式 |
C30H31ClN4O4 |
| 溶剂 |
DMSO |
| 纯度 | 98% |
| 存储温度 | -20℃ |
相关说明文档
储备液配置
|
浓度
体积
质量
|
1mg | 5mg | 10mg |
| 1 mM | 1.8280 mL | 9.1401 mL | 18.2802 mL |
| 5 mM | 0.3656 mL | 1.8280 mL | 3.6560 mL |
| 10 mM | 0.1828 mL | 0.9140 mL | 1.8280 mL |
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