Cryptotanshinone
(Cryptotanshinon; Tanshinone c)Cryptotanshinone is an inhibitor of oncogenic protein tyrosine phosphatase SHP2.
CAS NO.：35825-57-1
| 规格 | 价格 | 库存 |
|---|---|---|
| 10mg | 300.00 | 现货 |
| 20mg | 500.00 | 现货 |
| 50mg | 900.00 | 现货 |
基本信息
|
Cryptotanshinone is a potent STAT3 inhibitor with IC50 of 4.6 μM, and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. It is also an AR inhibitor to suppress androgen/AR-mediated cell growth and PSA expression by blocking AR dimerization and the AR-coregulator complex formation. Cryptotanshinone has anti-atherosclerosis, neuroprotective, anti-cancer,and anti-neointimal formation activities. Cryptotanshinone reverses DEX-induced androgen excess and ovarian IR in mice through activation of insulin signaling and the regulation of glucose transporters and hormone-synthesizing enzymes, it has an inhibitory effect on MMP-9 production and migration of human aortic smooth muscle cells treated with TNF-alpha in a dose-dependent manner. |
|
| CAS | 35825-57-1 |
| 分子量 | 296.36 |
| 分子式 | C₁₉H₂₀O₃ |
| 溶剂 | DMSO |
| 纯度 | 98% |
| 存储温度 | -20℃ |
相关说明文档
储备液配置
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浓度
体积
质量
|
1mg | 5mg | 10mg |
| 1 mM | 3.3743 mL | 16.8714 mL | 33.7427 mL |
| 5 mM | 0.6749 mL | 3.3743 mL | 6.7485 mL |
| 10 mM | 0.3374 mL | 1.6871 mL | 3.3743 mL |
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