Betulin
Betulin is a derivative of Betulinic Acid (B330250), used in the treatment of cancer and HIV disease. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
CAS NO.：473-98-3
| 规格 | 价格 | 库存 |
|---|---|---|
| 50mg | 500.00 | 现货 |
| 100mg | 800.00 | 现货 |
| 200mg | 1200.00 | 现货 |
基本信息
|
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line. Betulin has hypoglycemic, antineoplastic, anti-HIV, antimalarial and anti-inflammatory activities. Betulin can improve hyperlipidemia and insulin resistance and reduce atherosclerotic plaques. Betulin inhibits pro-inflammatory cytokines expression and NF-κB signaling activation through STAT3 signaling, it is associated with activation of AMP kinase and inhibition of mTOR/p70S6K/pS6 signaling in these cells. |
|
| CAS | 473-98-3 |
| 分子量 | 442.72 |
| 分子式 | C₃₀H₅₀O₂ |
| 溶剂 | DMSO |
| 纯度 | 98% |
| 存储温度 | -20℃ |
相关说明文档
储备液配置
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浓度
体积
质量
|
1mg | 5mg | 10mg |
| 1 mM | 2.2588 mL | 11.2938 mL | 22.5876 mL |
| 5 mM | 0.4518 mL | 2.2588 mL | 4.5175 mL |
| 10 mM | 0.2259 mL | 1.1294 mL | 2.2588 mL |
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