Fraxin
(Fraxoside; Paviin)白蜡树内酯的一种糖苷,并具有抗氧化、抗炎和抗转移活性。通过抑制环腺苷酸磷酸二酯酶表现出抗氧化活性。
CAS NO.:524-30-1
规格 | 价格 | 库存 |
---|---|---|
5mg | 600.00 | 现货 |
10mg | 1100.00 | 现货 |
20mg | 1900.00 | 现货 |
基本信息
Fraxin is a coumarin glycoside that has been found in Fraxinus and has anti-inflammatory activity. It inhibits formation of 5-hydroxyeicosatetraenoic acid (5-HETE) from arachidonic acid in rat polymorphonuclear leukocytes when used at concentrations ranging from 1 to 1,000 µM in vitro.Fraxin inhibits production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells (IC50 = 84.5 µM). It also decreases LPS-induced TNF-α, IL-6, IL-1β, NF-ĸB, and NLRP3 expression in the lung in mouse models of acute lung injury and endotoxic shock when administered at doses ranging from 10 to 40 mg/kg. |
|
CAS | 524-30-1 |
分子量 | 370.31 |
分子式 | C₁₆H₁₈O₁₀ |
溶剂 | DMSO |
纯度 | 98% |
存储温度 | -20℃ |
相关说明文档
储备液配置
浓度
体积
质量
|
1mg | 5mg | 10mg |
1 mM | 2.7004 mL | 13.5022 mL | 27.0044 mL |
5 mM | 0.5401 mL | 2.7004 mL | 5.4009 mL |
10 mM | 0.2700 mL | 1.3502 mL | 2.7004 mL |
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