NSC-281668
(PRIMA-1)PRIMA-1 (NSC-281668) 是一种突变型 p53 复活剂，可恢复 TP53 突变型甲状腺癌细胞对组蛋白甲基化抑制剂 3-Deazaneplanocin A 的敏感性。
CAS NO.：5608-24-2
| 规格 | 价格 | 库存 |
|---|---|---|
| 5mg | 500.00 | 现货 |
| 10mg | 700.00 | 现货 |
| 25mg | 1500.00 | 现货 |
| 50mg | 2250.00 | 现货 |
基本信息
|
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism. |
|
| CAS | 5608-24-2 |
| 分子量 | 199.25 |
| 分子式 |
C10H17NO3 |
| 溶剂 |
H2O |
| 纯度 | 98% |
| 存储温度 | -20℃ |
相关说明文档
储备液配置
|
浓度
体积
质量
|
1mg | 5mg | 10mg |
| 1 mM | 5.0188 mL | 25.0941 mL | 50.1882 mL |
| 5 mM | 1.0038 mL | 5.0188 mL | 10.0376 mL |
| 10 mM | 0.5019 mL | 2.5094 mL | 5.0188 mL |
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