Peimine
(Verticine; Dihydroisoimperialine)具有很好抗炎症活性
CAS NO.:23496-41-5
规格 | 价格 | 库存 |
---|---|---|
5mg | 630.00 | 现货 |
10mg | 980.00 | 现货 |
20mg | 1760.00 | 现货 |
100mg | 7350.00 | 现货 |
基本信息
Peimine is an alkaloid that has been found in Fritillaria and has diverse biological activities, including ion channel inhibitory, anti-tussive, anticancer, and anti-inflammatory properties. It is an inhibitor of voltage-gated sodium channel 1.7 (Nav1.7; IC50= 47.2 µM) and human-ether-a-go-go (hERG), also known as Kv11.1 (IC50 = 43.7 µM).It increases the latent period of coughs, decreases the number of coughs, and has expectorant activity in a mouse model of ammonia liquor-induced cough when administered at a dose of 3 mg/kg.Peimine (2.5, 5, and 10 µM) inhibits the growth of DU145, LNCaP, and PC3 prostate cancer, but not RWPE-1 non-cancerous, cells.It also induces phosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) in, and apoptosis of, PC3 cells and inhibits PC3 cell invasion, migration, and epithelial-to-mesenchymal transition. Peimine (10, 20, or 50 mg/animal) reduces tumor growth in a PC3 mouse xenograft model. It decreases IL-1β-induced nitric oxide (NO) and prostaglandin E2 production and reduces inducible NO synthase (iNOS) and COX-2 protein levels in primary mouse articular chondrocytes in vitro.It also decreases the severity of osteoarthritis-associated histopathological alterations in a mouse model of osteoarthritis when administered at a dose of 20 mg/kg. |
|
CAS | 23496-41-5 |
分子量 | 431.65 |
分子式 |
C27H45NO3 |
溶剂 |
DMSO |
纯度 | 98% |
存储温度 | 4℃ |
相关说明文档
储备液配置
浓度
体积
质量
|
1mg | 5mg | 10mg |
1 mM | 2.3167 mL | 11.5835 mL | 23.1669 mL |
5 mM | 0.4633 mL | 2.3167 mL | 4.6334 mL |
10 mM | 0.2317 mL | 1.1583 mL | 2.3167 mL |
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