Hederacoside C
有祛痰性、支气管扩张剂、抗菌等效应
CAS NO.:14216-03-6
规格 | 价格 | 库存 |
---|---|---|
5mg | 760.00 | 现货 |
10mg | 1200.00 | 现货 |
25mg | 2460.00 | 现货 |
50mg | 3700.00 | 现货 |
基本信息
Hederacoside C is a saponin that has been found in K. pictus and has anti-inflammatory activity.It is an inhibitor of acetylcholinesterase (AChE; IC50 = 31.3 μM).Hederacoside C (0.5-5 μg) inhibits mutagenicity induced by aflatoxin B1 in S. typhimurium agar cultures from 21 to 67%. It reduces TNF-α, IL-1β, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity in isolated mouse peritoneal macrophages stimulated by LPS when used at concentrations ranging from 5 to 10 μM.Hederacoside C (0.02 mg/kg) reduces carrageenan-induced hind paw edema by 37% compared to vehicle control in a rat model of acute inflammation.It reduces scopolamine-induced memory impairment and increases latency in a passive avoidance test and spontaneous alteration in a Y-maze in mice by 100 and 59%, respectively, when administered at a dose of 40 mg/kg.Hederacoside C (5 mg/kg, i.p.) reduces serum levels of TNF-α and IL-1β in LPS-challenged mice by 60 and 65%, respectively. |
|
CAS | 14216-03-6 |
分子量 | 1221.38 |
分子式 |
C₅₉H₉₆O₂₆ |
溶剂 |
DMSO |
纯度 | 98% |
存储温度 | -20℃ |
相关说明文档
储备液配置
浓度
体积
质量
|
1mg | 5mg | 10mg |
1 mM | 0.8187 mL | 4.0937 mL | 8.1875 mL |
5 mM | 0.1637 mL | 0.8187 mL | 1.6375 mL |
10 mM | 0.0819 mL | 0.4094 mL | 0.8187 mL |
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